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Page 1
CCR9 antagonism: potential in the treatment of Inflammatory Bowel Disease.
Wendt E, Keshav S. Wendt E, et al. Clin Exp Gastroenterol. 2015 Apr 7;8:119-30. doi: 10.2147/CEG.S48305. eCollection 2015. Clin Exp Gastroenterol. 2015. PMID: 25897254 Free PMC article. Review.
Directly targeting the subset of alpha4beta7 expressing cells that co-express CC chemokine receptor 9 (CCR9), using the orally administered antagonist, CCX282-B, also known as vercirnon, has also been evaluated in Phase II and III trials that have produced mixed res …
Directly targeting the subset of alpha4beta7 expressing cells that co-express CC chemokine receptor 9 (CCR9), using the orally admini …
Oxidized lipids and lysophosphatidylcholine induce the chemotaxis, up-regulate the expression of CCR9 and CXCR4 and abrogate the release of IL-6 in human monocytes.
Rolin J, Vego H, Maghazachi AA. Rolin J, et al. Toxins (Basel). 2014 Sep 23;6(9):2840-56. doi: 10.3390/toxins6092840. Toxins (Basel). 2014. PMID: 25251539 Free PMC article.
Lipids through regulation of chronic inflammation play key roles in the development of various diseases. Here, we report that a mixed population of human primary monocytes migrated towards LPC, as well as oxidized linoleic acid isoforms 9-S-HODE, 9-R-HODE and 13-R-HODE. .. …
Lipids through regulation of chronic inflammation play key roles in the development of various diseases. Here, we report that a mixed …
Chemokine receptor antagonists: part 2.
Pease JE, Horuk R. Pease JE, et al. Expert Opin Ther Pat. 2009 Feb;19(2):199-221. doi: 10.1517/13543770802641353. Expert Opin Ther Pat. 2009. PMID: 19441918 Review.
OBJECTIVE/METHOD: This second part of the series concludes the review by describing antagonists for CCR5, CCR8, CCR9, CXCR3, CXCR4, and promiscuous antagonists. CONCLUSION: Chemokine receptor antagonists have found mixed success as therapeutics. ...
OBJECTIVE/METHOD: This second part of the series concludes the review by describing antagonists for CCR5, CCR8, CCR9, CXCR3, CXCR4, a …
Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells.
Liang Y, Hasturk H, Elliot J, Noronha A, Liu X, Wetzler LM, Massari P, Kantarci A, Winter HS, Farraye FA, Ganley-Leal LM. Liang Y, et al. Clin Immunol. 2011 Jan;138(1):33-40. doi: 10.1016/j.clim.2010.09.003. Epub 2010 Oct 14. Clin Immunol. 2011. PMID: 20947433
Although oral or nasal vaccination methods would be ideal, current strategies have yielded mixed success. Toll-like receptor 2 (TLR2) ligands are effective adjuvants and are currently used in the Haemophilus influenzae type B vaccine. Induction of humoral immunity in the m …
Although oral or nasal vaccination methods would be ideal, current strategies have yielded mixed success. Toll-like receptor 2 (TLR2) …
Compartment-specific immunity in the human gut: properties and functions of dendritic cells in the colon versus the ileum.
Mann ER, Bernardo D, English NR, Landy J, Al-Hassi HO, Peake ST, Man R, Elliott TR, Spranger H, Lee GH, Parian A, Brant SR, Lazarev M, Hart AL, Li X, Knight SC. Mann ER, et al. Gut. 2016 Feb;65(2):256-70. doi: 10.1136/gutjnl-2014-307916. Epub 2015 Feb 9. Gut. 2016. PMID: 25666191 Free PMC article.
DESIGN: Human DC from paired colonic and ileal samples were characterised by flow cytometry, electron microscopy or used to stimulate T cell responses in a mixed leucocyte reaction. RESULTS: A lower proportion of colonic DC produced pro-inflammatory cytokines (tumour necro …
DESIGN: Human DC from paired colonic and ileal samples were characterised by flow cytometry, electron microscopy or used to stimulate T cell …
Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model.
Jacobs JP, Ortiz-Lopez A, Campbell JJ, Gerard CJ, Mathis D, Benoist C. Jacobs JP, et al. Arthritis Rheum. 2010 Jul;62(7):1921-32. doi: 10.1002/art.27470. Arthritis Rheum. 2010. PMID: 20506316 Free PMC article.
The functional relevance of chemokine induction was assessed by transferring serum into mice deficient in CCR1-7, CCR9, CXCR2, CXCR3, CXCR5, CX(3)CR1, CCL2, or CCL3. Further mechanistic analysis of CXCR2 involved treatment of arthritic mice with a CXCR2 antagonist, bone ma …
The functional relevance of chemokine induction was assessed by transferring serum into mice deficient in CCR1-7, CCR9, CXCR2, CXCR3, …
Oral Vaccination with Attenuated Salmonella typhimurium-Delivered TsPmy DNA Vaccine Elicits Protective Immunity against Trichinella spiralis in BALB/c Mice.
Wang L, Wang X, Bi K, Sun X, Yang J, Gu Y, Huang J, Zhan B, Zhu X. Wang L, et al. PLoS Negl Trop Dis. 2016 Sep 2;10(9):e0004952. doi: 10.1371/journal.pntd.0004952. eCollection 2016 Sep. PLoS Negl Trop Dis. 2016. PMID: 27589591 Free PMC article.
Cytokine analysis also showed a significant increase in the Th1 (IFN-gamma, IL-2) and Th2 (IL-4, 5, 6, 10) responses in lymphocytes from the spleen and MLNs of immunized mice upon stimulation with TsPmy protein. The expression of the homing receptors CCR9/CCR10 on antibody …
Cytokine analysis also showed a significant increase in the Th1 (IFN-gamma, IL-2) and Th2 (IL-4, 5, 6, 10) responses in lymphocytes from the …